The Role of miRNAs in Gastric Cancer

Despite promising developments of treatment, the mortality of gastric cancer remains high. MicroRNAs (miRNAs) are non-coding RNA molecules. There are extensive evidences that miRNAs play a dual role, as oncogenes or tumor suppressors through regulating cell proliferation, differentiation, and apoptosis. Additionally, some miRNAs, as promising diagnostic and prognostic biomarkers, are specifically related to gastric cancer. In the current review, we have summarized recent data concerning miRNAs in patient with gastric cancer, allowing us a better understanding miRNA as the prognostic and diagnostic biomarkers and the new targets for clinical therapeutic interventions for gastric cancer. *Corresponding author: Guo-Hua Tang, Life Science Research Center, University of South China, Hengyang, P.R. China, E-mail: [email protected] Received July 17, 2013; Accepted August 08, 2013; Published August 11, 2013 Citation: Tang GH, Tang M, Xie YJ (2013) The Role of miRNAs in Gastric Cancer. J Gastroint Dig Syst 3: 129. doi: 10.4172/2161-069X.1000129 Copyright: © 2013 Tang GH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.